Spot Defy Overnight Acne Treatment .5oz
Details
2026 Glamour Beauty & Wellness Award Winner: Best Acne Treatment.
“Its clay and sulfur formula dries down into a thin, protective layer across your blemish…my pimples are noticeably smaller and less irritated [by morning]" – T.K., Glamour editor
A fast-acting, precision spot treatment to clear acne and allow it to heal overnight – without irritation. 5% medicinal colloidal sulfur treats blackheads and whiteheads, absorbs excess sebum, and reduces acne bacteria to prevent repeat breakouts. Natural kaolin and bentonite draw out clogging impurities, as niacinamide and a barrier-building blend of lilac, hibiscus, lavender, gotu kola, oregano and thyme target post-acne dark spots and leave skin soothed. Skin is clearer, smoother, calmer in the morning. Free of problematic benzoyl peroxide.
Features
- 5% sulfur overnight acne spot treatment
- For sensitive, acne-prone skin
- For breakouts, clogged + enlarged pores , flakiness + rough texture, dull skin
- Formulated with colloidal sulfur (OTC) at 5%, bentonite and kaolin clays + niacinamide
- 0.5 oz product weight
- Gluten-free/vegan
- Made in USA
How to Use
- PM: On clean skin, spot-apply a thin layer to affected areas.
- Cleanse skin in the morning.
- Warnings: For external use only. Keep out of reach of children. When using this product, skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. when using this product apply only to areas with acne.
The Experience
- Feels Like: a comforting clay
- Smells Like: effective sulfur
Clinical Studies + Proof
- 92% say it helps reduce inflammation of acne
- 84% say it helps reduce the size of pimples
- 87% say it visibly improves the overall appearance of their acne-prone skin
- 84% say it made their skin look more clear
- 89% say it’s gentle and non-irritating
*based on a 2 day consumer perception study of 38 men and women ages 18-55 of all Fitzpatrick levels. Visit bioelements directly for full study results.
Responsibility developed + tested
- Responsibility developed + tested: dermatologist-tested and formulated with ingredients backed by established research, this formula undergoes rigorous quality and stability testing to ensure safety, consistency, and performance. We never test on animals.
Esthetician’s Note
- “What spot defy “defies” is time itself – as it works overnight to quickly reduce inflammation and the size of breakouts without damaging the surrounding healthy skin. It’s designed to clear the breakout while also repairing the skin’s barrier. And that makes your skin better able to navigate future breakout cycles.” – Beth Bialko, licensed esthetician and Bioelements Senior Director of Education
Key Ingredients
- Colloidal Sulfur (OTC) 5%: Treats + clears acne, absorbs excess sebum, unclogs pores and denies growth of acne bacteria; prevents acne + PIH; calms inflamed skin. Superior to and safer than benzoyl peroxide.
- Bentonite and Kaolin: Natural clays create an occlusive barrier to draw out oil + impurities; helps hold ingredient contact to blemishes.
- Niacinamide: Skin-strengthening vitamin B3 - helps improve the appearance of environmental damage, problem pores, uneven tone, lines, and dullness.
- Dipotassium Glycyrrhizate: From licorice root, helps soothe skin and help skin texture.
- Centella Asiatica Extract (gotu kola/tiger grass): Adaptogenic natural herb to help strengthen and balance the skin.
- Hibiscus Rosa-Sinensis Flower Extract: High in polysaccharides to help the skin retain moisture.
- Lavandula Angustifolia (Lavender) Extract: Flower extract, helps calm skin.
- Origanum Vulgare Leaf Extract: From oregano, a botanical extract that is high contains the antioxidant, carvacrol.
- Thymus Vulgaris (Thyme) Extract: Pure, plant-derived botanical that targets excess sebum.
Full Ingredient List
- Active Ingredient: Sulfur 5%
- Inactive ingredients: Water (Aqua, Eau), Kaolin, Cetearyl Alcohol, Glyceryl Stearate SE, Glycerin, Butylene Glycol, Bentonite, Acacia Senegal Gum, Phenoxyethanol, Niacinamide, Maltodextrin, Ethylhexylglycerin, Sodium PCA, Xanthan Gum, Tocopheryl Acetate, Syringa Vulgaris (Lilac) Extract, Quartz, Dipotassium Glycyrrhizate, Centella Asiatica Extract, Hibiscus Rosa-Sinensis Flower Extract, Lavandula Angustifolia (Lavender) Extract, Origanum Vulgare Leaf Extract, Thymus Vulgaris (Thyme) Extract
- Gluten-free; vegan
Details
2026 Glamour Beauty & Wellness Award Winner: Best Acne Treatment.
“Its clay and sulfur formula dries down into a thin, protective layer across your blemish…my pimples are noticeably smaller and less irritated [by morning]" – T.K., Glamour editor
A fast-acting, precision spot treatment to clear acne and allow it to heal overnight – without irritation. 5% medicinal colloidal sulfur treats blackheads and whiteheads, absorbs excess sebum, and reduces acne bacteria to prevent repeat breakouts. Natural kaolin and bentonite draw out clogging impurities, as niacinamide and a barrier-building blend of lilac, hibiscus, lavender, gotu kola, oregano and thyme target post-acne dark spots and leave skin soothed. Skin is clearer, smoother, calmer in the morning. Free of problematic benzoyl peroxide.
Features
- 5% sulfur overnight acne spot treatment
- For sensitive, acne-prone skin
- For breakouts, clogged + enlarged pores , flakiness + rough texture, dull skin
- Formulated with colloidal sulfur (OTC) at 5%, bentonite and kaolin clays + niacinamide
- 0.5 oz product weight
- Gluten-free/vegan
- Made in USA
How to Use
- PM: On clean skin, spot-apply a thin layer to affected areas.
- Cleanse skin in the morning.
- Warnings: For external use only. Keep out of reach of children. When using this product, skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. when using this product apply only to areas with acne.
The Experience
- Feels Like: a comforting clay
- Smells Like: effective sulfur
Clinical Studies + Proof
- 92% say it helps reduce inflammation of acne
- 84% say it helps reduce the size of pimples
- 87% say it visibly improves the overall appearance of their acne-prone skin
- 84% say it made their skin look more clear
- 89% say it’s gentle and non-irritating
*based on a 2 day consumer perception study of 38 men and women ages 18-55 of all Fitzpatrick levels. Visit bioelements directly for full study results.
Responsibility developed + tested
- Responsibility developed + tested: dermatologist-tested and formulated with ingredients backed by established research, this formula undergoes rigorous quality and stability testing to ensure safety, consistency, and performance. We never test on animals.
Esthetician’s Note
- “What spot defy “defies” is time itself – as it works overnight to quickly reduce inflammation and the size of breakouts without damaging the surrounding healthy skin. It’s designed to clear the breakout while also repairing the skin’s barrier. And that makes your skin better able to navigate future breakout cycles.” – Beth Bialko, licensed esthetician and Bioelements Senior Director of Education
Key Ingredients
- Colloidal Sulfur (OTC) 5%: Treats + clears acne, absorbs excess sebum, unclogs pores and denies growth of acne bacteria; prevents acne + PIH; calms inflamed skin. Superior to and safer than benzoyl peroxide.
- Bentonite and Kaolin: Natural clays create an occlusive barrier to draw out oil + impurities; helps hold ingredient contact to blemishes.
- Niacinamide: Skin-strengthening vitamin B3 - helps improve the appearance of environmental damage, problem pores, uneven tone, lines, and dullness.
- Dipotassium Glycyrrhizate: From licorice root, helps soothe skin and help skin texture.
- Centella Asiatica Extract (gotu kola/tiger grass): Adaptogenic natural herb to help strengthen and balance the skin.
- Hibiscus Rosa-Sinensis Flower Extract: High in polysaccharides to help the skin retain moisture.
- Lavandula Angustifolia (Lavender) Extract: Flower extract, helps calm skin.
- Origanum Vulgare Leaf Extract: From oregano, a botanical extract that is high contains the antioxidant, carvacrol.
- Thymus Vulgaris (Thyme) Extract: Pure, plant-derived botanical that targets excess sebum.
Full Ingredient List
- Active Ingredient: Sulfur 5%
- Inactive ingredients: Water (Aqua, Eau), Kaolin, Cetearyl Alcohol, Glyceryl Stearate SE, Glycerin, Butylene Glycol, Bentonite, Acacia Senegal Gum, Phenoxyethanol, Niacinamide, Maltodextrin, Ethylhexylglycerin, Sodium PCA, Xanthan Gum, Tocopheryl Acetate, Syringa Vulgaris (Lilac) Extract, Quartz, Dipotassium Glycyrrhizate, Centella Asiatica Extract, Hibiscus Rosa-Sinensis Flower Extract, Lavandula Angustifolia (Lavender) Extract, Origanum Vulgare Leaf Extract, Thymus Vulgaris (Thyme) Extract
- Gluten-free; vegan
